May I suggest... The Golden Gate Chronicles series by Karen Barnett!
This series of books is set in turn of the century San Fransisco, including the infamous earthquake, its aftermath, and reconstruction. There is a focus on the medical research and advances of the time with unforgettable characters. The third book, Through the Shadows, just released this month!
I will be giving away a hardcover copy of the second book in the series, Beyond the Ashes, which can be read as a stand alone. Enter to win in the Giveaway Tools widget below!
Where better to rebuild and face one's fears than in 1906 San Francisco, a city rising from the ashes? Ruby Marshall, a young widow, is certain she'll discover new purpose assisting her brother Robert with his cancer research, but she doesn't anticipate finding new love. Dr. Gerald Larkspur dreams of filling his empty home with family, but he'd always hoped it would be a wife and children. In the aftermath of the great earthquake, the rooms are overflowing with extended family and friends left homeless by the disaster. When Robert's widowed sister arrives, the close quarters seem close indeed. Ruby and Gerald's fledgling romance is put at risk when Gerald develops symptoms of the very disease they're striving to cure. Together they must ask--is it worth a second chance at love when time might be short?